Jacek Zielonka Selected Research

Superoxides (Superoxide)

1/2021	Detection of extracellular superoxide in isolated human immune cells and in an animal model of arterial hypertension using hydropropidine probe and HPLC analysis.
1/2020	Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon.
1/2020	Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I.
1/2020	Increased formation of reactive oxygen species during tumor growth: Ex vivo low-temperature EPR and in vivo bioluminescence analyses.
1/2018	Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and targeted therapies.
12/2017	Modified Metformin as a More Potent Anticancer Drug: Mitochondrial Inhibition, Redox Signaling, Antiproliferative Effects and Future EPR Studies.
8/2015	Antiproliferative effects of mitochondria-targeted cationic antioxidants and analogs: Role of mitochondrial bioenergetics and energy-sensing mechanism.
9/2012	Alterations in bioenergetic function induced by Parkinson's disease mimetic compounds: lack of correlation with superoxide generation.
12/2008	MyD88-dependent, superoxide-initiated inflammation is necessary for flow-mediated inward remodeling of conduit arteries.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Jacek Zielonka Research Topics

Disease

26	Neoplasms (Cancer) 01/2020 - 04/2006
6	Breast Neoplasms (Breast Cancer) 11/2019 - 11/2010
4	Mitochondrial Diseases (Mitochondrial Disease) 11/2020 - 01/2012
4	Neoplasm Metastasis (Metastasis) 01/2020 - 11/2008
4	Pancreatic Neoplasms (Pancreatic Cancer) 12/2017 - 08/2015
4	Parkinson Disease (Parkinson's Disease) 11/2014 - 09/2012
3	Carcinogenesis 01/2020 - 01/2018
3	Inflammation (Inflammations) 01/2018 - 12/2008
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 12/2017
2	Hypoxia (Hypoxemia) 01/2020 - 11/2019
2	Cardiotoxicity 05/2019 - 01/2013
2	Lung Neoplasms (Lung Cancer) 01/2019 - 05/2018
2	Cardiomyopathies (Cardiomyopathy) 01/2013 - 02/2009
1	Septic Shock (Toxic Shock Syndrome) 06/2022
1	Reperfusion Injury 01/2022
1	Hypertension (High Blood Pressure) 01/2021
1	Brain Injuries (Brain Injury) 01/2021
1	Radiation Injuries (Radiation Sickness) 01/2021
1	Adenocarcinoma 01/2020
1	Thrombosis (Thrombus) 01/2020
1	Dyslipidemias (Dyslipidemia) 01/2020
1	Melanoma (Melanoma, Malignant) 01/2020
1	Mouth Neoplasms (Oral Cancer) 01/2020
1	Triple Negative Breast Neoplasms 05/2019
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019
1	Brain Neoplasms (Brain Tumor) 05/2018
1	Infections 01/2018
1	Colonic Neoplasms (Colon Cancer) 01/2018
1	Neuroinflammatory Diseases 11/2017
1	Disease Progression 10/2017
1	Anosmia 11/2014
1	Carcinoma (Carcinomatosis) 10/2014

Drug/Important Bio-Agent (IBA)

11	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2020 - 11/2008
9	Superoxides (Superoxide)IBA 01/2021 - 12/2008
6	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2020 - 08/2015
5	Oxidants (Oxidizing Agents)IBA 01/2020 - 09/2012
5	AntioxidantsIBA 01/2018 - 10/2011
5	Pharmaceutical PreparationsIBA 01/2018 - 10/2011
5	triphenylphosphoniumIBA 12/2017 - 02/2009
4	Metformin (Glucophage)FDA LinkGeneric 05/2019 - 01/2016
4	Phosphotransferases (Kinase)IBA 12/2017 - 11/2010
3	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2013
3	Adenosine Triphosphate (ATP)IBA 01/2020 - 06/2013
3	nitroxylIBA 01/2018 - 10/2011
3	Hypoglycemic Agents (Hypoglycemics)IBA 12/2017 - 01/2016
3	mito-carboxy proxylIBA 08/2015 - 01/2012
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 06/2022 - 04/2006
2	NitrogenIBA 01/2020 - 08/2013
2	PeroxiredoxinsIBA 01/2020 - 01/2019
2	Oxygen (Dioxygen)IBA 01/2020 - 08/2013
2	Superoxide DismutaseIBA 11/2019 - 01/2012
2	Dexrazoxane (Zinecard)FDA LinkGeneric 05/2019 - 01/2013
2	Chelating AgentsIBA 05/2019 - 03/2011
2	IronIBA 05/2019 - 03/2011
2	EnzymesIBA 01/2019 - 04/2006
2	acetovanillone (apocynin)IBA 11/2017 - 11/2014
2	diapocyninIBA 11/2014 - 08/2013
2	Leucine (L-Leucine)FDA Link 11/2014 - 08/2013
2	Free RadicalsIBA 10/2014 - 08/2014
2	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2013 - 02/2009
2	Antineoplastic Agents (Antineoplastics)IBA 01/2012 - 04/2006
2	mitoquinoneIBA 11/2010 - 02/2009
2	UbiquinoneIBA 11/2010 - 02/2009
2	Nitric Oxide Synthase (NO Synthase)IBA 02/2009 - 04/2006
1	Fluorescein (Funduscein)FDA LinkGeneric 01/2022
1	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2021
1	hydropropidineIBA 01/2021
1	Cytochrome P-450 CYP2E1 (CYP2E1)IBA 11/2020
1	Aconitate Hydratase (Aconitase)IBA 01/2020
1	src-Family KinasesIBA 01/2020
1	4-Nitroquinoline-1-oxide (4 Nitroquinoline 1 oxide)IBA 01/2020
1	oxidized low density lipoproteinIBA 01/2020
1	Cysteine (L-Cysteine)FDA Link 01/2020
1	Scavenger Receptors (Scavenger Receptor)IBA 01/2020
1	LipidsIBA 01/2020
1	LDL Lipoproteins (beta Lipoproteins)IBA 01/2020
1	LuciferasesIBA 01/2020
1	magnololIBA 01/2020
1	LuciferinsIBA 01/2020
1	Lysine (L-Lysine)FDA Link 11/2019
1	Transcription Factors (Transcription Factor)IBA 11/2019
1	Deferasirox FDA Link 05/2019
1	Protein Isoforms (Isoforms)IBA 01/2019
1	NADP (NADPH)IBA 01/2019
1	Oxidoreductases (Dehydrogenase)IBA 01/2019
1	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 01/2019
1	lonidamineIBA 01/2019
1	honokiolIBA 05/2018
1	monooxyethylene trimethylolpropane tristearate (MTTS)IBA 01/2018
1	Therapeutic UsesIBA 01/2018
1	IntegrinsIBA 01/2018
1	NADPH Oxidases (NAD(P)H oxidase)IBA 12/2017
1	Radiation-Sensitizing AgentsIBA 01/2016
1	Fluorescent Dyes (Fluorescent Probes)IBA 10/2014
1	Reactive Nitrogen SpeciesIBA 10/2014
1	LipopolysaccharidesIBA 08/2014

Therapy/Procedure

6	Therapeutics 05/2019 - 10/2011
1	Radiotherapy 01/2021
1	Chemoprevention 01/2020
1	Drug Therapy (Chemotherapy) 05/2019